This text examines the ontological nature of the whole and its relationship to the surrounding environment. The author emphasizes that every true whole actively distinguishes itself from its context, even when it remains dependent on that environment as its prerequisite. This process of integration and unification is not merely a construct of human perception but is an inherent activity of the whole itself. The document further explores how such entities establish and maintain their integrity, including the regulation of matter and energy exchange, often referred to as metabolism in biological terms. A central concern is identifying the source and origin of the activities that sustain this internal unity. Finally, the text suggests the necessity of redefining the concept of the subject in relation to these integrating forces. The reflection aims at a deeper understanding of the active agent responsible for the existence and continuity of a whole, calling for a reevaluation of subjectivity within the framework of systemic integrity.