This text presents a critical reflection on Václav Němec's perspective, which restrictively defines the phenomenon of guilt as occurring only within human relationships. The author argues that such a narrow interpretation is unsustainable today, as the sense of guilt increasingly extends toward animals, plants, and the biosphere. A significant focus is placed on guilt toward oneself, where harming others is seen as simultaneously damaging one's own potential and the ability to fulfill one's mission. The discussion expands to include collective guilt and the biblical concept of intergenerational responsibility. Furthermore, the author invokes Anaximander's metaphysical idea that existence itself constitutes guilt against everything that remains uncreated. Ultimately, the text warns against the prejudiced exclusion of these broader ethical and ontological dimensions. It suggests that guilt is a multifaceted phenomenon involving deep responsibilities toward the self, the environment, and existence itself, which cannot be reduced to simple interpersonal harm without losing its essential philosophical meaning.